tag:blogger.com,1999:blog-5081537833114332620.post7894665305960885275..comments2023-10-01T08:39:28.907-07:00Comments on High Tower Pharmacology: New "Anabolic:" AegelineS.P. O'Brienhttp://www.blogger.com/profile/05914114201709643845noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-5081537833114332620.post-8708181175339235292016-01-19T21:54:18.917-08:002016-01-19T21:54:18.917-08:00PLEASE SEE THE "Aegeline and nonviral_hepatit...PLEASE SEE THE "Aegeline and nonviral_hepatitis" SECTION OF THE WIKIPEDIA ARTICLE ON THE PLANT "Aegle marmelos" BEFORE USING THIS SUBSTANCE, WHICH CITES THE FDA AND DOJ INITIATIVES AGAINST ONE SUPPLIER WHOSE SUBSTITUTION OF SYNTHETIC AGENT FOR PLANT EXTRACT RESULTED IN A DEATH BY LIVER FAILURE, AND SEVERAL ADDITIONAL CASES REQUIRING CRITICAL MEDICAL ATTENTION (INCLUDING NEED FOR LIVER TRANSPLANT). OR, TRUST MR. O'BRIEN'S "If I was to guess…". M-E Duban, PhD<br /><br />https://en.wikipedia.org/wiki/Aegle_marmelos#Aegeline_and_nonviral_hepatitisAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-5081537833114332620.post-25563555775233352013-11-20T09:46:20.663-08:002013-11-20T09:46:20.663-08:00Interesting, Thanks for the prompt and thorough re...Interesting, Thanks for the prompt and thorough response. Very true about phase 1s, but I guess that the companies argument is that it comes from whatever plant and has been consumed (although I believe that this shouldn't apply to pure compounds extracted from said plants.) for many years is the supplements version of human trials. Intriguingly, I was using 2 products that contained a lower and high dose of aegeline, OEPro thermo powder and versa-1 respectively, by USPlabs together and had to have blood levels taken around week 7 of an 8 week run I was planning. My liver enzymes were well within normal range and nothing in their ratios nor was there anything else to suggest something was amiss. Obviously I quit after I'd read about the potential link, and have noticed nothing since. This happened around the time they made the link, a month ago or so. Thanks for providing this blog, I love reading and learning from your work. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5081537833114332620.post-2081280935636570572013-11-20T03:55:47.089-08:002013-11-20T03:55:47.089-08:00If I was to guess, I would surmise that oxidation ...If I was to guess, I would surmise that oxidation would be the most likely primary & consistent method of metabolism. Conjugation is not as efficient with para-hydroxyl constituents, and amide hydrolysis is simply too slow and too variable. S.P. O'Brienhttps://www.blogger.com/profile/05914114201709643845noreply@blogger.comtag:blogger.com,1999:blog-5081537833114332620.post-11012537999842497712013-11-20T03:53:33.099-08:002013-11-20T03:53:33.099-08:00There are a few ways this compound could be metabo...There are a few ways this compound could be metabolized: oxidation, amide hydrolysis, or conjugation. Amide hydrolysis produces (non-energetically) a benzene compound with an extended conjugated hydrocarbon chain capable of "anti-oxidation" of radicals through resonance stabilization. Conjugation would produce more water soluble products capable of urinary/biliary excretion. Oxidation would (generally) produce non-amine containing carbon skeletons in addition to (some) free ammonia. If conjugation or hydrolysis are the preferred methods of metabolism, I would suspect there would be little, if any, potential hepatotoxicity. On the other hand, if oxidation is the preferred manner, then hepatotoxicity is possible. This is why pharmacokinetic studies are important prior to releasing a fairly unknown compound into the free market. Phase I clinical trials would also be nice.S.P. O'Brienhttps://www.blogger.com/profile/05914114201709643845noreply@blogger.comtag:blogger.com,1999:blog-5081537833114332620.post-69910975011825782792013-11-19T19:21:19.308-08:002013-11-19T19:21:19.308-08:00Any speculation as to negative pharmacological int...Any speculation as to negative pharmacological interactions with this compound and the liver? If your chemistry knowledge is as extensive as your physiology/pharmacology, what about toxic synth byproducts/impurities if they are using a synthesized version of the compound? Lots of supps using it are being pulled and the FDA thinks they have linked Aegeline to causing liver damage.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5081537833114332620.post-85423932000177281292013-01-09T21:57:43.547-08:002013-01-09T21:57:43.547-08:00Why no discussion of beta-phenylacrylic acid, aka ...Why no discussion of beta-phenylacrylic acid, aka trans-cinnamic acid, a major active constituent of cinnamon? It's been shown to increase GLUT-4 in skeletal muscle, inhibit PTP1B and act as an insulin secretagogue. Surely some of those potential mechanisms could explain an anabolic effect, assuming these metabolites are present in significant quantities after ingestion.<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/20929506<br />http://www.ncbi.nlm.nih.gov/pubmed/18651742<br /><br />What is the oral bioavailability of aegeline? <br /><br />Also, what is the mean elimination half-life of DMAA?<br /><br />Anonymousnoreply@blogger.com